TWNK

Across TCGA pan-cancer cohorts, TWNK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TWNK data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TWNK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TWNK expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where TWNK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.170	1.000	.038	6	view →
PDAC	OS	Quartile	II,III,IV	0.319	0.644	.029	3	view →
LSCC	OS	Quartile	All	0.951	0.715	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TWNK–HNSC (DFS)

Open the HNSC breakdown →