TWIST2

Across TCGA patient cohorts, TWIST2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWIST2-associated genes across cancer lineages are MC2R, RNU4-56P, and TRAJ11. Each is linked with TWIST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWIST2-to-partner and partner-to-TWIST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC2R grouped by TWIST2-low versus TWIST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWIST2→partner) and Y-score (partner→TWIST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MC2R →	+0.064	+4.863	.001	<.001	3	1
UCEC	RNU4-56P →	+0.348	+4.997	.002	.003	3	1
UCEC	TRAJ11 →	+1.115	+4.813	<.001	.001	3	1
UCEC	PSG3 →	+0.128	+3.831	<.001	.009	3	1
UCEC	LINC00370 →	+0.143	+4.616	.002	.001	3	1
UCEC	SC4MOP →	+0.089	+4.868	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MC2R by TWIST2 expression — UCEC

Explore this box plot interactively →