TVP23B

Across TCGA pan-cancer cohorts, TVP23B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TVP23B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TVP23B RNA is repressed in tumor relative to normal tissue. In most cancer types TVP23B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, BLCA, and STAD are the cancer types where TVP23B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TVP23B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.119	<.001	7	view →
BLCA	All	All	+0.548	.001	7	view →
STAD	All	All	+0.513	.003	6	view →
THCA	Male	All	−0.482	<.001	6	view →
LUAD	All	All	+0.352	<.001	5	view →
LUSC	Male	All	+0.512	<.001	4	view →
BRCA	Female	II,III,IV	+0.227	.003	4	view →
UCEC	All	IV	−1.575	.042	2	view →
CHOL	All	All	+1.150	.001	2	view →
PAAD	All	All	+0.890	.008	2	view →
LIHC	All	III,IV	+0.418	.017	2	view →
ESCA	All	All	+0.665	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TVP23B–KICH

Open the KICH breakdown →