TUT4

Across TCGA pan-cancer cohorts, TUT4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TUT4 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TUT4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TUT4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where TUT4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.946	0.680	.001	35	view →
CCRCC	OS	Quartile	All	0.960	0.803	.020	14	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	DFS	Quartile	All	0.927	0.723	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TUT4–LSCC (OS)

Open the LSCC breakdown →