TUT4

Across TCGA cell cohorts, TUT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUT4-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Heterochromatin organization, and Positive regulation of double-strand break repair. Each is linked with TUT4 in more than 15 cancer types. Because this analysis shows association rather than direction, both TUT4-to-partner and partner-to-TUT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by TUT4-low versus TUT4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TUT4→partner) and Y-score (partner→TUT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.069	+0.789	<.001	<.001	3	16
BONE	Heterochromatin organization →	+0.092	+0.967	<.001	<.001	3	16
BONE	Positive regulation of double-strand break repair →	+0.100	+1.024	<.001	<.001	3	16
STOMACH	Heterochromatin formation →	+0.091	+1.530	.001	<.001	3	16
BONE	Positive regulation of DNA metabolic process →	+0.073	+0.672	<.001	<.001	3	15
SOFT_TISSUE	Centrosome duplication →	+0.126	+1.163	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,287 associations by consensus.

Negative regulation of gene expression, epigenetic by TUT4 expression — BONE

Explore this box plot interactively →