TUT4

Across TCGA cell cohorts, TUT4 mutation is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TUT4-associated genes across cancer lineages are OR52K1, LY6G6F, and LMX1A. Each is linked with TUT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUT4-to-partner and partner-to-TUT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K1 grouped by TUT4-low versus TUT4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUT4→partner) and Y-score (partner→TUT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR52K1 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	LY6G6F →	+0.040	+5.087	<.001	.004	3	1
BLOOD_Myeloma	LMX1A →	+0.014	+3.906	<.001	.009	3	1
BLOOD_Myeloma	LCN6 →	+0.035	+3.906	.001	.009	3	1
SKIN	PNPLA5 →	+0.052	+4.273	<.001	.006	3	1
SKIN	IL2 →	+0.016	+4.415	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

OR52K1 by TUT4 expression — URINARY_TRACT

Explore this box plot interactively →