TUT1

Across TCGA patient cohorts, TUT1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUT1-associated genes across cancer lineages are mTOR_pS2448, Notch1, and XBP1. Each is linked with TUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUT1-to-partner and partner-to-TUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TUT1-low versus TUT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUT1→partner) and Y-score (partner→TUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.097	-1.980	.049	.009	3	2
UCEC	Notch1 →	+0.144	+1.817	.001	.015	3	2
UCEC	XBP1 →	-0.140	-1.794	.002	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.684	+2.522	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.184	-1.584	.026	.017	3	1
UCEC	A-Raf_pS299 →	-0.097	-1.700	.013	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by TUT1 expression — UCEC

Explore this box plot interactively →