TUT1

Across TCGA cell cohorts, TUT1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUT1-associated genes across cancer lineages are CLDN8, KRTAP4-4, and TEX43. Each is linked with TUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUT1-to-partner and partner-to-TUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN8 grouped by TUT1-low versus TUT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUT1→partner) and Y-score (partner→TUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLDN8 →	+0.008	+3.234	.003	.008	3	1
BLOOD_Leukemia	KRTAP4-4 →	+0.013	+4.569	<.001	.003	3	1
BLOOD_Leukemia	TEX43 →	+0.070	+3.969	<.001	.009	3	1
BLOOD_Leukemia	CCT8L2 →	+0.012	+3.289	<.001	.009	3	1
BLOOD_Leukemia	BTBD17 →	+0.122	+3.906	<.001	.003	3	1
BLOOD_Leukemia	LRCOL1 →	+0.427	+3.681	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CLDN8 by TUT1 expression — BLOOD_Leukemia

Explore this box plot interactively →