TUSC8

Across TCGA pan-cancer cohorts, TUSC8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TUSC8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TUSC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUSC8 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

COAD, BRCA, and THCA are the cancer types where TUSC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUSC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.416	<.001	11	view →
BRCA	Female	II,III,IV	−1.251	<.001	8	view →
THCA	Female	All	−0.104	<.001	8	view →
KIRC	All	II,III,IV	−0.097	<.001	7	view →
HNSC	All	II,III,IV	−0.684	.001	5	view →
LUAD	All	All	+0.533	<.001	4	view →
KICH	All	All	−0.171	.004	4	view →
CHOL	Female	All	−1.819	.001	2	view →
LIHC	Male	All	+1.089	<.001	2	view →
ESCA	Female	All	−1.576	.046	1	view →
KIRP	All	All	−0.058	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TUSC8–COAD

Open the COAD breakdown →