Across TCGA pan-cancer cohorts, TUSC7 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TUSC7’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TUSC7 RNA is repressed in tumor relative to normal tissue. In most cancer types TUSC7 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where TUSC7 tumor–normal differential expression is most reproducible.