TUSC3

Across TCGA pan-cancer cohorts, TUSC3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TUSC3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TUSC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUSC3 expression acts as an unfavorable survival marker, although some lineages such as GBM and OV show a favorable association.

PDAC, GBM, and OV are the cancer types where TUSC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.514	0.900	.016	24	view →
GBM	DFS	Quartile	All	0.479	0.245	.006	13	view →
OV	DFS	Median	All	1.000	0.864	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TUSC3–PDAC (DFS)

Open the PDAC breakdown →