TUSC3

Across TCGA pan-cancer cohorts, TUSC3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TUSC3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TUSC3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TUSC3 is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

HNSC, PDAC, and OV are the cancer types where TUSC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUSC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.334	.025	4	view →
PDAC	Female	All	−0.727	.032	2	view →
OV	All	All	+0.681	.019	2	view →
LUAD	Female	All	−0.564	.001	1	view →
LSCC	Female	All	+0.282	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TUSC3–HNSC

Open the HNSC breakdown →