TUSC3

Across TCGA patient cohorts, TUSC3 mutation is significantly associated with the RNA expression of many other genes, with 3,630 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUSC3-associated genes across cancer lineages are RN7SKP188, GPER1, and SLIT3. Each is linked with TUSC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TUSC3-to-partner and partner-to-TUSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP188 grouped by TUSC3-low versus TUSC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUSC3→partner) and Y-score (partner→TUSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP188 →	+0.123	+4.564	<.001	.003	3	3
UCEC	GPER1 →	-0.802	-3.584	.001	.002	3	3
SKCM	SLIT3 →	-0.773	-2.081	.004	.005	3	3
SKCM	SAMD5 →	+0.842	+3.182	.002	.009	3	3
UCEC	LLPH →	+0.539	+3.364	<.001	<.001	3	3
UCEC	MAP6 →	-0.714	-3.692	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,630 associations by consensus.

RN7SKP188 by TUSC3 expression — COAD

Explore this box plot interactively →