TUSC3

Across TCGA patient cohorts, TUSC3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUSC3-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and PDCD4. Each is linked with TUSC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TUSC3-to-partner and partner-to-TUSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TUSC3-low versus TUSC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUSC3→partner) and Y-score (partner→TUSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.269	+2.222	.014	.011	3	3
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.575	.007	.010	3	2
UCEC	PDCD4 →	-0.450	-1.700	.024	.044	3	2
SKCM	PI3K-p85 →	+0.212	+3.169	.030	.017	3	2
UCEC	RAD51 →	+0.132	+1.700	.026	.044	3	2
UCEC	Rictor_pT1135 →	-0.099	-2.321	.022	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FoxM1 by TUSC3 expression — UCEC

Explore this box plot interactively →