TUSC3

Across TCGA cell cohorts, TUSC3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TUSC3-associated genes across cancer lineages are GSG1L2, OR2M4, and HES3. Each is linked with TUSC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUSC3-to-partner and partner-to-TUSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by TUSC3-low versus TUSC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUSC3→partner) and Y-score (partner→TUSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	OR2M4 →	+0.058	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	HES3 →	+0.099	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.027	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	OR56A4 →	+0.033	+3.927	.009	.004	3	1
BLOOD_Lymphoma	PRSS45P →	+0.227	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GSG1L2 by TUSC3 expression — LARGE_INTESTINE

Explore this box plot interactively →