Across TCGA pan-cancer cohorts, TUSC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TUSC1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TUSC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TUSC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where TUSC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.764	0.432	.008	19	view →
CCRCC	DFS	Quartile	III,IV	0.831	0.513	.048	2	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →
PDAC	OS	Tertile	All	0.377	0.598	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TUSC1 tumor-vs-normal RNA expression · all TUSC1 data types