Across TCGA cell cohorts, TUSC1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TUSC1-associated genes across cancer lineages are CENPVL3, SEL1L2, and ZNF479. Each is linked with TUSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUSC1-to-partner and partner-to-TUSC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUSC1→partner) and Y-score (partner→TUSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPVL3 →	+0.329	+3.920	<.001	.005	3	2
URINARY_TRACT	SEL1L2 →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	ZNF479 →	+0.047	+4.087	<.001	.009	3	1
URINARY_TRACT	FSCB →	+0.041	+4.217	.001	.005	3	1
URINARY_TRACT	OR2T6 →	+0.005	+4.087	<.001	.009	3	1
CNS	CNMD →	+0.366	+3.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

TUSC1 survival (RNA) · tumor vs normal (RNA) · all TUSC1 data types