TULP4

Across TCGA patient cohorts, TULP4 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TULP4-associated genes across cancer lineages are Smad4, ATM, and ASNS. Each is linked with TULP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TULP4-to-partner and partner-to-TULP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by TULP4-low versus TULP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TULP4→partner) and Y-score (partner→TULP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.141	+2.321	.003	.033	3	4
UCEC	ATM →	-0.474	-1.861	<.001	.001	3	4
COAD	ASNS →	+0.499	+1.915	<.001	.009	3	4
STAD	Caveolin-1 →	-0.818	-2.700	.007	.005	3	3
STAD	cIAP →	+0.134	+3.000	.021	.034	2	4
STAD	c-Kit →	-0.255	-2.700	.046	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Smad4 by TULP4 expression — COAD

Explore this box plot interactively →