TULP2

Across TCGA patient cohorts, TULP2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TULP2-associated genes across cancer lineages are eIF4E, STAT5a, and Caspase-8. Each is linked with TULP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TULP2-to-partner and partner-to-TULP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TULP2-low versus TULP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TULP2→partner) and Y-score (partner→TULP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.087	.048	.005	3	2
UCEC	STAT5a →	+0.333	+1.678	.030	.023	3	2
UCEC	Caspase-8 →	-0.223	-2.432	.020	.018	3	2
UCEC	C-Raf →	+0.189	+2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.106	-1.664	.005	.023	3	1
UCEC	EGFR →	-0.162	-1.678	.008	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by TULP2 expression — UCEC

Explore this box plot interactively →