TUFT1

Across TCGA pan-cancer cohorts, TUFT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TUFT1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TUFT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TUFT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where TUFT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.318	<.001	38	view →
HNSC	DFS	Quartile	II,III,IV	0.815	0.532	.015	18	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	14	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.574	.011	14	view →
CCRCC	OS	Quartile	II,III,IV	0.573	0.982	.009	13	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TUFT1–UCEC (DFS)

Open the UCEC breakdown →