TUFT1

Across TCGA patient cohorts, TUFT1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUFT1-associated genes across cancer lineages are JNK2, MEK1, and SF2. Each is linked with TUFT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUFT1-to-partner and partner-to-TUFT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TUFT1-low versus TUFT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUFT1→partner) and Y-score (partner→TUFT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.242	+3.009	.026	.019	3	1
UCEC	MEK1 →	+0.405	+3.169	.043	.020	3	1
UCEC	SF2 →	-0.174	-3.156	.003	.020	3	1
UCEC	Axl →	+0.373	+2.843	.003	.035	2	1
UCEC	Caveolin-1 →	+1.203	+3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by TUFT1 expression — UCEC

Explore this box plot interactively →