TUFM

Across TCGA patient cohorts, TUFM mutation is significantly associated with the RNA expression of many other genes, with 352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUFM-associated genes across cancer lineages are OR10AF1P, WBP1LP6, and SFMBT1. Each is linked with TUFM in more than 1 cancer types. Because this analysis shows association rather than direction, both TUFM-to-partner and partner-to-TUFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AF1P grouped by TUFM-low versus TUFM-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUFM→partner) and Y-score (partner→TUFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR10AF1P →	+0.109	+8.471	<.001	.005	3	2
STAD	WBP1LP6 →	+0.084	+3.778	.001	.002	3	2
UCEC	SFMBT1 →	+0.663	+3.483	.007	.002	3	1
UCEC	CENPN →	+0.701	+3.343	.002	.005	3	1
UCEC	GPX4 →	+0.591	+3.754	.002	<.001	3	1
UCEC	MVD →	+0.592	+2.617	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

OR10AF1P by TUFM expression — BRCA

Explore this box plot interactively →