TUFM

Across TCGA patient cohorts, TUFM mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUFM-associated genes across cancer lineages are 14-3-3_beta, MSH2, and MSH6. Each is linked with TUFM in more than 1 cancer types. Because this analysis shows association rather than direction, both TUFM-to-partner and partner-to-TUFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TUFM-low versus TUFM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUFM→partner) and Y-score (partner→TUFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-2.571	.018	.011	3	1
UCEC	MSH2 →	-0.378	-2.295	<.001	.033	3	1
UCEC	MSH6 →	-0.568	-2.321	<.001	.033	3	1
UCEC	p70-S6K →	+0.206	+3.019	.021	.019	2	2
UCEC	Annexin-1 →	+0.578	+2.827	.018	.035	3	1
UCEC	p90 RSK →	+0.302	+2.598	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by TUFM expression — UCEC

Explore this box plot interactively →