TUBGCP3

Across TCGA patient cohorts, TUBGCP3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBGCP3-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with TUBGCP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBGCP3-to-partner and partner-to-TUBGCP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TUBGCP3-low versus TUBGCP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBGCP3→partner) and Y-score (partner→TUBGCP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.535	-1.754	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.213	-1.125	.004	.033	3	2
UCEC	eIF4E →	+0.159	+3.713	.012	<.001	3	2
UCEC	FoxM1 →	+0.166	+1.321	.033	.012	3	2
UCEC	INPP4B →	-0.268	-1.765	.006	.011	3	2
UCEC	Notch1 →	+0.149	+2.179	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by TUBGCP3 expression — UCEC

Explore this box plot interactively →