TUBG1

Across TCGA patient cohorts, TUBG1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBG1-associated genes across cancer lineages are eIF4E, ER-alpha, and IGFBP2. Each is linked with TUBG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBG1-to-partner and partner-to-TUBG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TUBG1-low versus TUBG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBG1→partner) and Y-score (partner→TUBG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.185	+3.000	.038	.036	3	1
UCEC	ER-alpha →	-0.815	-2.308	.019	.033	3	1
UCEC	IGFBP2 →	-0.872	-2.584	.001	.010	3	1
UCEC	MEK1 →	+0.428	+2.906	.005	.001	3	1
UCEC	MSH2 →	-0.434	-3.690	<.001	.001	3	1
UCEC	MSH6 →	-0.372	-2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by TUBG1 expression — UCEC

Explore this box plot interactively →