TUBE1

Across TCGA patient cohorts, TUBE1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,312 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TUBE1-associated genes across cancer lineages are SH3KBP1, CDC42EP4, and GCSHP5. Each is linked with TUBE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBE1-to-partner and partner-to-TUBE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TUBE1 versus SH3KBP1 in LSCC, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBE1→partner) and Y-score (partner→TUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3KBP1 →	-0.496	-0.281	<.001	<.001	3	2
LSCC	CDC42EP4 →	+0.710	+0.281	<.001	.001	3	2
UCEC	GCSHP5 →	-0.649	-0.489	<.001	.002	3	2
BRCA	CYP4A22-AS1 →	-0.813	-0.480	<.001	<.001	3	2
BRCA	POLR2F →	+0.593	+0.412	.001	<.001	3	2
LSCC	PAK1IP1 →	+0.578	+0.302	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,312 associations by consensus.

TUBE1 vs SH3KBP1 — LSCC

Explore this scatter interactively →