TUBBP5

Across TCGA pan-cancer cohorts, TUBBP5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TUBBP5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TUBBP5 RNA is repressed in tumor relative to normal tissue. In most cancer types TUBBP5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, BLCA, and LUSC are the cancer types where TUBBP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBBP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.058	<.001	11	view →
BLCA	All	III,IV	+0.862	.039	5	view →
LUSC	All	All	+0.635	.001	5	view →
LIHC	All	II,III,IV	+0.490	.009	5	view →
CHOL	All	All	+1.489	.002	4	view →
BRCA	All	II,III,IV	+0.346	.016	4	view →
STAD	Male	III,IV	+1.293	.002	3	view →
COAD	All	All	+0.456	.017	3	view →
KICH	All	III,IV	−0.999	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TUBBP5–KIRC

Open the KIRC breakdown →