TUBBP1

Across TCGA patient cohorts, TUBBP1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBBP1-associated genes across cancer lineages are Myosin-IIa, eIF4E, and Annexin-1. Each is linked with TUBBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBBP1-to-partner and partner-to-TUBBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa grouped by TUBBP1-low versus TUBBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBBP1→partner) and Y-score (partner→TUBBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Myosin-IIa →	+0.274	+2.822	.031	.034	3	2
UCEC	eIF4E →	+0.174	+3.013	.031	.018	3	2
UCEC	Annexin-1 →	+0.499	+3.321	.013	.009	3	2
UCEC	ATM →	-0.459	-1.678	.008	.023	3	2
UCEC	14-3-3_beta →	-0.093	-1.664	.016	.023	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Myosin-IIa by TUBBP1 expression — SKCM

Explore this box plot interactively →