Across TCGA pan-cancer cohorts, TUBB8P6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TUBB8P6’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where TUBB8P6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUBB8P6 is over-expressed in tumor.
ESCA and COAD are the cancer types where TUBB8P6 tumor–normal differential expression is most reproducible.