TUBB6

Across TCGA pan-cancer cohorts, TUBB6 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TUBB6 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TUBB6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB6 expression acts as an unfavorable survival marker.

COAD, ACC, and HNSC are the cancer types where TUBB6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.111	0.871	<.001	24	view →
ACC	OS	Median	All	0.188	0.820	<.001	15	view →
HNSC	OS	Median	III,IV	0.021	0.675	<.001	12	view →
ESCA	DFS	Median	All	0.075	0.533	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LIHC	OS	Median	All	0.105	0.774	.002	9	view →
CESC	DFS	Median	II,III,IV	0.263	0.710	.034	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	OS	Median	All	0.238	0.799	<.001	6	view →
LUSC	OS	Median	II,III,IV	0.501	0.732	.002	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TUBB6–COAD (OS)

Open the COAD breakdown →