TUBB6

Across TCGA pan-cancer cohorts, TUBB6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TUBB6 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TUBB6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB6 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where TUBB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.346	1.000	.018	24	view →
CCRCC	OS	Median	All	0.909	1.000	.019	16	view →
LSCC	OS	Tertile	II,III,IV	0.576	0.869	.009	12	view →
GBM	OS	Tertile	All	0.625	0.224	.006	9	view →
PDAC	DFS	Quartile	III,IV	0.212	0.907	.002	6	view →
LUAD	OS	Quartile	III,IV	0.410	0.924	.009	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TUBB6–UCEC (OS)

Open the UCEC breakdown →