TUBB6

Across TCGA patient cohorts, TUBB6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB6-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and STAT3_pY705. Each is linked with TUBB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TUBB6-to-partner and partner-to-TUBB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TUBB6-low versus TUBB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB6→partner) and Y-score (partner→TUBB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.541	+1.604	.013	.041	3	4
SKCM	ERK2 →	+0.321	+2.824	.007	.034	3	2
SKCM	STAT3_pY705 →	-0.368	-3.000	.017	.036	3	2
SKCM	eEF2 →	+0.452	+3.000	.016	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.000	.005	.009	3	1
UCEC	Ku80 →	+0.206	+1.515	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by TUBB6 expression — UCEC

Explore this box plot interactively →