TUBB6

Across TCGA cell cohorts, TUBB6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,614 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TUBB6-associated GO terms across cancer lineages are Regulation of metaphase plate congression, Positive regulation of mitotic cell cycle phase transition, and Establishment of apical/basal cell polarity. Each is linked with TUBB6 in more than 13 cancer types. Because this analysis shows association rather than direction, both TUBB6-to-partner and partner-to-TUBB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase plate congression grouped by TUBB6-low versus TUBB6-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB6→partner) and Y-score (partner→TUBB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of metaphase plate congression →	+0.127	+2.471	<.001	<.001	2	14
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.096	+1.672	<.001	<.001	3	13
STOMACH	Establishment of apical/basal cell polarity →	+0.245	+4.559	<.001	<.001	3	13
BREAST	Mitotic sister chromatid segregation →	+0.114	+2.911	<.001	<.001	3	12
BREAST	Sister chromatid segregation →	+0.108	+2.881	<.001	<.001	3	12
PANCREAS	Positive regulation of cell cycle process →	+0.072	+1.490	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,614 associations by consensus.

Regulation of metaphase plate congression by TUBB6 expression — PANCREAS

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