TUBB6

Across TCGA cell cohorts, TUBB6 mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TUBB6-associated genes across cancer lineages are PCI-34051, CDK9_5576, and CX-5461. Each is linked with TUBB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB6-to-partner and partner-to-TUBB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCI-34051 grouped by TUBB6-low versus TUBB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB6→partner) and Y-score (partner→TUBB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCI-34051 →	+0.440	+2.646	.021	.047	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.568	+2.649	.029	.046	2	1
LARGE_INTESTINE	CX-5461 →	+0.650	+2.652	.027	.045	2	1
LARGE_INTESTINE	Sabutoclax →	+0.471	+2.769	.026	.040	1	1
LARGE_INTESTINE	GSK429286A →	+0.312	+2.652	.047	.045	1	1
LARGE_INTESTINE	Y-39983 →	+0.509	+2.652	.018	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PCI-34051 by TUBB6 expression — LARGE_INTESTINE

Explore this box plot interactively →