Across TCGA pan-cancer cohorts, TUBB4BP8 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TUBB4BP8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TUBB4BP8 RNA is repressed in tumor relative to normal tissue. In most cancer types TUBB4BP8 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where TUBB4BP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB4BP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.088	<.001	5	view →
LUAD	Female	II,III,IV	−0.116	.001	4	view →
BRCA	All	All	+0.119	.032	2	view →
ESCA	All	All	−0.090	.039	1	view →
KIRC	Male	All	−0.007	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TUBB4BP8 RNA expression & survival · all TUBB4BP8 data types