Across TCGA pan-cancer cohorts, TUBB4B Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TUBB4B data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.
The strongest signal is observed in mesothelioma (MESO), where higher TUBB4B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB4B expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.
MESO, LUSC, and LIHC are the cancer types where TUBB4B Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.