Across TCGA pan-cancer cohorts, TUBB4B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TUBB4B data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TUBB4B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TUBB4B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where TUBB4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	33	view →
PDAC	DFS	Quartile	All	0.491	0.327	.032	8	view →
GBM	DFS	Tertile	All	0.481	0.273	.019	6	view →
LUAD	OS	Median	All	0.997	0.923	.017	2	view →
HNSC	DFS	Quartile	III,IV	0.866	0.584	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TUBB4B tumor-vs-normal RNA expression · all TUBB4B data types