Across TCGA patient cohorts, TUBB4B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB4B-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ERK2. Each is linked with TUBB4B in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB4B-to-partner and partner-to-TUBB4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB4B→partner) and Y-score (partner→TUBB4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.999	+3.341	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.000	.028	.032	3	1
UCEC	ERK2 →	+0.275	+2.000	.001	.032	3	1
UCEC	Notch1 →	+0.244	+3.472	<.001	.002	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.505	-1.986	.012	.032	3	1
UCEC	PDCD4 →	-0.568	-2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TUBB4B survival (RNA) · tumor vs normal (RNA) · all TUBB4B data types