TUBB2B

Across TCGA pan-cancer cohorts, TUBB2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TUBB2B data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TUBB2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB2B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

UCEC, HNSC, and GBM are the cancer types where TUBB2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.305	0.814	.020	8	view →
HNSC	DFS	Median	III,IV	0.909	0.679	.006	5	view →
GBM	OS	Quartile	All	0.630	0.979	.007	4	view →
PDAC	OS	Quartile	II,III,IV	0.239	0.539	.044	3	view →
LUAD	OS	Tertile	II,III,IV	0.895	1.000	.030	1	view →
LSCC	DFS	Median	III,IV	0.916	0.655	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TUBB2B–UCEC (OS)

Open the UCEC breakdown →