TUBB1

Across TCGA pan-cancer cohorts, TUBB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TUBB1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TUBB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where TUBB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.845	1.000	.020	13	view →
UCEC	OS	Median	All	0.904	1.000	.008	12	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.890	.012	6	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	6	view →
LUAD	OS	Median	III,IV	0.750	0.998	.025	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TUBB1–LSCC (DFS)

Open the LSCC breakdown →