TUBB1

Across TCGA patient cohorts, TUBB1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB1-associated genes across cancer lineages are eEF2, eIF4E, and A-Raf_pS299. Each is linked with TUBB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB1-to-partner and partner-to-TUBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TUBB1-low versus TUBB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB1→partner) and Y-score (partner→TUBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.339	+1.874	.013	.049	3	1
UCEC	eIF4E →	+0.183	+2.087	.024	.005	3	1
UCEC	A-Raf_pS299 →	-0.094	-2.459	.041	.019	3	1
UCEC	MEK1 →	+0.568	+3.247	<.001	<.001	3	1
UCEC	MSH6 →	-0.429	-3.459	<.001	.005	3	1
UCEC	mTOR_pS2448 →	-0.134	-1.861	.019	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by TUBB1 expression — UCEC

Explore this box plot interactively →