TUBB1

Across TCGA cell cohorts, TUBB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,512 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TUBB1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Promoter clearance during DNA-templated transcription, and RNA polymerase II promoter clearance. Each is linked with TUBB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both TUBB1-to-partner and partner-to-TUBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by TUBB1-low versus TUBB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB1→partner) and Y-score (partner→TUBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.067	+0.193	<.001	<.001	3	13
SOFT_TISSUE	Promoter clearance during DNA-templated transcription →	+0.160	+0.258	<.001	.001	1	14
SOFT_TISSUE	RNA polymerase II promoter clearance →	+0.160	+0.258	<.001	.001	1	14
OESOPHAGUS	Regulation of mRNA catabolic process →	+0.077	+0.171	<.001	<.001	3	12
BONE	Viral transcription →	+0.134	+0.244	<.001	<.001	3	12
OESOPHAGUS	Regulation of RNA stability →	+0.079	+0.203	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,512 associations by consensus.

Negative regulation of gene expression, epigenetic by TUBB1 expression — BONE

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