TUBB1

Across TCGA cell cohorts, TUBB1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TUBB1-associated genes across cancer lineages are MYPN, NPFFR1, and TRPM3. Each is linked with TUBB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB1-to-partner and partner-to-TUBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYPN grouped by TUBB1-low versus TUBB1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB1→partner) and Y-score (partner→TUBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYPN →	+0.027	+3.567	<.001	.003	3	1
BLOOD_Leukemia	NPFFR1 →	+0.014	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	TRPM3 →	+0.037	+3.847	<.001	.004	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	ABCG4 →	+0.263	+3.451	.001	.005	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MYPN by TUBB1 expression — BLOOD_Leukemia

Explore this box plot interactively →