Across TCGA pan-cancer cohorts, TUBB Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TUBB data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TUBB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB expression acts as an unfavorable survival marker.

UCEC and LUSC are the cancer types where TUBB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.225	0.772	<.001	18	view →
LUSC	DFS	Median	All	0.177	0.661	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TUBB tumor-vs-normal RNA expression · all TUBB data types