TUBAP8

Across TCGA pan-cancer cohorts, TUBAP8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TUBAP8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TUBAP8 RNA is repressed in tumor relative to normal tissue. In most cancer types TUBAP8 is over-expressed in tumor, although a few such as LUSC and ESCA show the opposite, repressed pattern.

LUSC, BRCA, and ESCA are the cancer types where TUBAP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBAP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−0.174	<.001	6	view →
BRCA	Female	All	+0.321	.001	4	view →
ESCA	All	II,III,IV	−0.175	.022	2	view →
HNSC	All	IV	+0.017	.015	2	view →
LUAD	Male	All	−0.082	.037	1	view →
KIRP	All	III,IV	+0.018	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TUBAP8–LUSC

Open the LUSC breakdown →