TUBAL3

Across TCGA patient cohorts, TUBAL3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBAL3-associated genes across cancer lineages are 4E-BP1, ERK2, and mTOR_pS2448. Each is linked with TUBAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBAL3-to-partner and partner-to-TUBAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TUBAL3-low versus TUBAL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBAL3→partner) and Y-score (partner→TUBAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.405	+2.815	<.001	.036	3	2
UCEC	ERK2 →	+0.222	+1.874	.002	.049	3	2
UCEC	mTOR_pS2448 →	-0.180	-2.302	.001	.005	3	2
UCEC	p62 Lck ligand →	+0.436	+2.009	<.001	.017	3	2
UCEC	PDCD4 →	-0.455	-1.678	.011	.023	3	2
UCEC	ATM →	-0.611	-1.678	<.001	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by TUBAL3 expression — COAD

Explore this box plot interactively →