Across TCGA patient cohorts, TUBA8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA8-associated genes across cancer lineages are 14-3-3_beta, G6PD, and ACC1. Each is linked with TUBA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA8-to-partner and partner-to-TUBA8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA8→partner) and Y-score (partner→TUBA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.081	-3.295	.044	.009	3	1
UCEC	G6PD →	-0.301	-3.156	.020	.018	3	1
UCEC	ACC1 →	+0.321	+3.183	.028	.009	3	1
UCEC	HER3 →	-0.225	-2.449	.041	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-2.321	.022	.034	3	1
UCEC	JNK2 →	+0.162	+2.415	.042	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TUBA8 survival (RNA) · tumor vs normal (RNA) · all TUBA8 data types