TUBA4A

Across TCGA pan-cancer cohorts, TUBA4A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TUBA4A data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TUBA4A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBA4A expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TUBA4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.693	0.911	.002	22	view →
HNSC	DFS	Tertile	III,IV	1.000	0.897	.021	12	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
GBM	DFS	Tertile	All	0.814	0.621	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TUBA4A–CCRCC (DFS)

Open the CCRCC breakdown →