TUBA3D

Across TCGA patient cohorts, TUBA3D mutation is significantly associated with the RNA expression of many other genes, with 4,054 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA3D-associated genes across cancer lineages are TIMM44, LSM5, and TFAM. Each is linked with TUBA3D in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA3D-to-partner and partner-to-TUBA3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by TUBA3D-low versus TUBA3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA3D→partner) and Y-score (partner→TUBA3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.427	+3.743	<.001	<.001	3	2
UCEC	LSM5 →	+0.408	+1.912	.007	.004	3	2
UCEC	TFAM →	+0.605	+2.769	.001	<.001	3	2
UCEC	PUS3 →	+0.409	+3.815	.001	<.001	3	2
UCEC	HBS1L →	+0.527	+3.815	<.001	<.001	3	2
UCEC	BRIX1 →	+0.481	+1.858	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,054 associations by consensus.

TIMM44 by TUBA3D expression — UCEC

Explore this box plot interactively →