TUBA3D

Across TCGA patient cohorts, TUBA3D mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA3D-associated genes across cancer lineages are HER3_pY1289, MEK1, and mTOR_pS2448. Each is linked with TUBA3D in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA3D-to-partner and partner-to-TUBA3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by TUBA3D-low versus TUBA3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA3D→partner) and Y-score (partner→TUBA3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.100	+2.189	.004	.034	3	2
UCEC	MEK1 →	+0.320	+2.459	.029	.019	3	2
UCEC	mTOR_pS2448 →	-0.185	-2.446	.001	.018	3	2
UCEC	ATM →	-0.542	-3.308	.002	.009	3	2
UCEC	c-Met_pY1235 →	+0.128	+3.009	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.594	+2.415	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HER3_pY1289 by TUBA3D expression — UCEC

Explore this box plot interactively →